Questions Surrounding Avandia� and its Effect on Bone

A small study to be published in an upcoming issue of the Journal of Clinical Endocrinology & Metabolism found that postmenopausal women who took Avandia^® (rosiglitazone) at 8mg/day for 14 weeks had greater reductions in hip bone density than women in a control group:

• - Total hip bone density fell in the Avandia group by 1.9%
  
• - Total hip bone density fell in the placebo group by 0.2%

Leading authors to conclude:

"Short-term therapy with rosiglitazone exerts detrimental skeletal effects, by inhibiting bone formation."

A reduction in bone density could increase the risk of fractures. That wont be welcome news to women with diabetes who already experience an increased risk of fractures - a finding reported by this journal last year.

Reuters reported:

"Morgan Stanley said in a note that an osteoporosis warning was now "very likely" to be added to the drugs label."

________
Avandia study, free author manuscript (pdf):
The peroxisome-proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and one mineral density in healthy postmenopausal women: a randomized, controlled trial

Avandia study, abstract:
The peroxisome-proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial

Reuters news summary:
New study fuels bone fears over Glaxos Avandia

JCEMs diabetes and bone fracture study, abstract:
Risk of Fracture in Women with Type 2 Diabetes: the Women’s Health Initiative Observational Study

Some Essential Bone Cancer Prevention Tips

Bone cancer may be primary or secondary in nature. If the origination of cancer is in the bone, it is referred to as primary bone cancer. If it will spread to the body from other body parts, it is known as secondary bone cancer. Some examples of primary bone cancer are histiocytoma, sarcoma and Osteosarcoma. Undoubtedly, there are some useful tips to prevent bone cancer. One of them is the awareness of the risk factors. It was suggested by a study that if fluorinated water is consumed by men, they are at a high risk of developing bone cancer. However, girls were not affected by the intake of fluorinated water. Therefore, a person must be aware of the conditions which increase the risk of bone cancer. Given below are few of them:

1. The risk of bone cancer is raised by Radiation therapy
2. Paget’s disease
3. Genetic conditions such as Li-Fraumeni syndrome
4. Renoblastoma
5. Children who are born with umbilical hernia
6. Rothmund- Thompson is also a very rare syndrome that is found in kids. Stunted growth is caused and the risk of Osteosarcoma is raised.

Some useful tips to prevent bone cancer are given below

1. People should have an awareness of their genes. They must find out a relative in their bloodline who has been diagnosed with this condition in the past.
2. One should stay away from lifestyle habits that are negative. The risk of stress and smoking is raised due to this. The intake of any form of tobacco increases the risk of developing cancer manifold.
3. Nutrition and diet play a very important role in the prevention of bone cancer. A check must be kept on the intake of calories. A person must stick to a diet that is low-fat. It is concluded by studies that if vegetables and fruits are included in the diet, there is a low risk for developing cancer. The intake of red meat and saturated fat must also be reduced.
4. Yoga and physical exercise are very effective in curing various medical disorders. The blood circulation is improved and the growth of cancer is limited.
5. Cancer must be diagnosed before metastasis. Experts must be consulted for detection and screening the condition before it will spread.
6. One can also follow some herbal tips for preventing bone cancer. The use of ginseng and turmeric must be incorporated in preparing food. There is a compound known as cur cumin which is present in turmeric. Various properties for fighting cancer are present in it.

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The author has given good information in this article about some essential tips to prevent bone cancer. You can also read about types of treatment for bone cancer http://www.onlymyhealth.com/types-treatment-bone-cancer-1295388770 at Onlymyhealth.

Author : Vanni

Human growth hormone supplement given to children who suffer with abnormally slow bone growth

Human Growth Hormone (HGH)

Growth is a very complex process, and requires the coordinated action of several hormones. Human growth hormone (HGH) is a protein hormone of about 190 amino acids that is synthesized and secreted by cells called somatotrophs in the anterior pituitary that promotes growth during childhood and adolescence. It is a major participant in control of several complex physiologic processes, including growth and metabolism.

Physiologic Effects of Human Growth Hormone (HGH)

A critical concept in understanding human growth hormone (HGH) activity is that it has two distinct types of effects:

- Direct effects are the result of growth hormone binding its receptor on target cells.

- Indirect effects are mediated primarily by a insulin-like growth factor-I (IGF-I), a hormone that is secreted from the liver and other tissues in response to growth hormone.

Symptoms of Human Growth Hormone (HGH) Deficiency

It is estimated that 10,000 to 15,000 children in the United States have growth failure due to human growth hormone (HGH) deficiency. Symptoms of human growth hormone (HGH) reduction include increased body fat, increased anxiety, social isolation, poor general health, and lack of positive well being. HGH has been the supplement of choice for many professional athletes over the years.

Causes of Human Growth Hormone (HGH) Deficiency

Human growth hormone (HGH)is a protein that is produced by the pituitary gland and is vital for normal growth. Human growth hormone (HGH) deficiency exists when this hormone is absent or produced in inadequate amounts. If other pituitary hormones are lacking, the condition is called hypopituitarism. When all the pituitary hormones are missing, the child has panhypopituitarism.

Sometimes no cause for hypopituitarism can be identified, or if a cause is suspected, it may be difficult to prove. Researchers are trying to learn more about the causes of human growth hormone deficiency and hypopituitadsm.

Treatment of Human Growth Hormone (HGH) Deficiency

Human growth hormone (HGH) deficiency is treated with injections of growth hormone. Some children receive three of four injections a week, while other receive daily injections. The treatment of human growth hormone (HGH) deficiency usually is carried out over several years, until the child achieves an acceptable adult height or maximum growth potential is reached. It is important to remember that growth is a slow process that is measured over months; children who expect to grow overnight when they start treatment will be disappointed.

If testing disclose other hormone deficiencies, medications are available to replace them; thyroid hormone, cortisol and sex hormones can be administered easily when found to be lacking. It is important that these hormones are taken as directed, because normal growth can occur only when all hormones are present in the proper amounts. Good nutrition and adequate rest are important for normal growth in all children.

Human Growth Hormone (HGH) Supplementation Benefits

Some of the benefits associated with Human growth hormone (HGH) supplementation include the reversal of common diseases associated with aging, improved brain activity and function, it strengthens connective tissue which reduces the probability of injury, incredible weight loss without any loss in lean mass, reduces wrinkles by rejuvenating the skin, it raises energy levels and brightens mood, promotes muscle growth, improves libido, improves functions of the lungs which increases the level of oxygen in the blood stream, provides immune system support and Thymus function, and probably the most impressive characteristic is, its ability to produce more muscle cells, something no steroid can do.

Human growth hormone (HGH) replacement in adults may have a beneficial effect on lipids. In a recent study, it was reported that short courses of Human growth hormone (HGH) reduced LDL (bad) cholesterol while it improved exercise capacity and cardiac function. Human growth hormone supplement given to children who suffer with abnormally slow bone growth to enable them to grow taller.

More Detail About Human Growth Hormone
Author By Rosa parks

Article Source : Human growth hormone supplement given to children who suffer with abnormally slow bone growth

The benefits of Plum fruit for bone health

Maybe you just know that Plum fruit is used only to overcome the constipation, but in fact this healthiest fruit that has other benefits for the health. The scientists found that women who have undergone menopause will avoid the attack of osteoporosis and fractures by eating prunes approximately 10 pieces per day.

University of Florida and Oklahoma have shown that dried plum was more beneficial than figs, dates, strawberries, apples, raisins or dried to increase bone density. Plum works to minimize damage to the bone that usually occurs when a person after the increase.

Throughout my career have been testing a lot of fruit to see its effect on bone. But no one ever has an effect as well as plums, said Bahram H. Arjmandi, professor from the University of Florida, who is also Head of the Department of Nutritional Sciences, Food, and American Sports.

All fruits and vegetables, he says, contain nutrients that are good. But only some of them contain useful for bone.

Arjmandi along with a group of researchers carried out tests for two groups of postmenopausal women. During the year, the first group consisted of 55 women were asked to consume 100 grams of dried plums or at least 10 pieces per day. Whereas the other group were asked to consume the dried apples with the same dose.

Based on research that looks all trial participants get calcium and vitamin D from both the food. But the group who ate dried plums has a mineral that makes bones more dense in the ulna compared with other groups. The ulna is one of the two long bones located in the forearm and spine.

In the first five-seven years after menopause, women at risk of bone loss around 3-5 percent per year, said Arjmandi. But it does not only happen to women, men aged about 65 years old will experience the same thing as a woman.

It is advisable to not wait until your bones are broken or have osteoporosis and need to get a doctors care. Do something meaningful and practical, like eating this healthiest fruit. Plums fruit can be eaten in any form and used as cooking recipes.

Diet And Exercise To Bone Reinforcement

Calcium plays an important role for maintaining bone health and strength to old age. But a study in Germany revealed the discovery, too much calcium may increase the risk of heart attack. The risk may be higher in women over the age of 40, which typically consume large doses of calcium in their bones to remain strong after menopause.

Actually, the consumption of calcium is not the only way to maintain healthy bones. You also have to combine it with exercise and a healthy diet. Here it is diet and exercise tips for stronger bones.

1. Eat Right
You should consume at least 1,000 mg of calcium per day, but avoid too much milk or taking supplements with the label high calcium. Would be healthier if you get it from the daily diet. The best foods for strong bones is skim milk, yogurt, salmon and sardines. Green vegetables such as broccoli and spinach are also very good for maintaining bone density, as well as dried fruits like raisins and oranges are eaten with breakfast cereal.

2. Add intake of Vitamin D
Vitamin D helps the body to absorb calcium, and usually are found mainly in fish such as salmon and mackerel. But the best sources of vitamin D comes from sunlight in the morning to get into the skin. Unfortunately, many people lack the benefits of vitamin D from sunlight because of their habit of applying sunscreen, citing fears of skin darkening or burning.

Though the sun is not always bad for the body. The morning sun between the hours of 6 to 9 is very good for growth and bone health. Simply drying your body in the sun for 10 minutes per day (remember, without sunscreen and wear long sleeves and sunglasses), have reduced the risk of bone loss of up to three times.

3. Sport
Another way is very important in strengthening the bone is to sports. What kind of physical activity? That exercise is associated with weight lifting, or exercise any mestimulasi and stretch.

You can try aerobics, dancing, brisk walking or lifting a dumbbell. Research shows, if not exercising, your body will release calcium through the urine, rather than keep it in your bones.

Ideally, people should perform moderate physical activity for 150 minutes per week. Simply put, the more time we spend to move the legs and arms, the less calcium is wasted from the body.